Programme

08:45 – 09:00

MH 2023

Welcome words
Michael Heneka, Director, Luxembourg Centre for Systems Biomedicine

Session 1: Microglia

09:00 – 10:00

Bart_credits Soeren Kracht klein

Plenary Talk 1:  Microglia in the diseased human CNS, from an -omics perspective
Bart Eggen, University Medical Center Groningen

10:00 – 10:30

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Microglia regulation of activity-dependent changes in neuronal metabolism and translation
Eric Klann, New York University

10:30 – 11:00

Coffee break (posters & industry exhibition)

11:00 – 11:30

Lennart Mucke poses for a portait at Gladstone Institutes on Oct. 7th, 2021.

Disrupting Pathogenic Links between Neural Network and Immune Cell Dysfunctions in Alzheimer’s Disease
Lennart Mucke, Gladstone Institute of Neurological Disease, University of California, San Francisco

11:30 – 12:00

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Impact of microglia on neuronal circuit functions
Tarja Malm, A.I. Virtanen Institute, University of Eastern Finland

12:00 – 12:15

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Exploring the effect of chronic synaptic activity inhibition on microglia dynamics in a mouse model of Alzheimer’s disease
Davide Tampellini, Institut Professeur Baulieu

12:15 – 12:30

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Luxembourg National Research Fund presentation
Gideon Gießelmann, Programme Manager, Luxembourg National Research Fund

12:15 – 13:30

Lunch (posters & industry exhibition)

13:30 – 14.00

Poster session

Session 2: Oligodendrocytes

14:00 – 15:00

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Plenary Talk 2: The role glia cells in de- and remyelination
Mikael Simons, Technical University Munich and German Center for Neurodegenerative Diseases (DZNE)

15:00 – 15:30

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Oligodendrocytes in brain energy metabolism and Alzheimer’s disease
Klaus-Armin Nave, Max Planck Institute of Multidisciplinary Sciences, University of Göttingen

15:30 – 15:45

Blitz Talks (selected from abstracts):

The transcription factor Pax6 regulates microglia phenotype and controls neuroinflammation (Klaus Hämäläinen, University of Paris Cité)

The protective PLCγ2-P522R variant enhances microglia immunometabolism
(Heli Jeskanen, University of Eastern Finland)

15:45 – 16:15

Coffee break (posters & industry exhibition)

Session 3: Astrocytes

16:15 – 16:45

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Reactive astrocytes in neurodegeneration
Shane Liddelow, New York University Grossmann School of Medicine

16:45 – 17:00

Blitz Talks (selected from abstracts):

Midbrain Monoaminergic Deficits drive Hippocampal Microglia-Astrocyte reactivity and Accelerate Alzheimer’s Pathology
(Gilda Loffredo, Università Campus Bio-Medico di Roma)

ABCA7 loss-of-function microglia lose their phagocytic ability and reactive profile in a humanized model of AD
(Jessie Premereur,VIB-CMN)

Session 4: Epigenetics

17:00 – 17:30

DZNE Standorte Ost
Magdeburg, Dresden, Göttingen

Studio-Portraits Arbeitsgruppenleiter

Non-Coding RNAs and Epigenetic Regulation in Astrocytes and Microglia: Insights into Neurodegenerative Diseases
André Fischer, University Medical Center Göttingen and German Center for Neurodegenerative Diseases (DZNE)

17:30 – 18:00

Gonçalo Castelo-branco

Single-Cell and Spatial Transcriptomics and Epigenomics of Oligodendroglia in Development and in Multiple Sclerosis
Gonçalo Castelo-Branco, Karolinska Institute

18:00 – 18:30

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How the concept of glia evolved – a historical journey
Helmut Kettenmann, Shenzhen University of Advanced Technology

Session 5: Inflammasomes & cGAS/STING

9:00 – 10:00

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Plenary Talk 3: Inflammasomes: from fundamental biology to new therapeutics for neuroinflammation
Kate Schroeder, Institute for Molecular Bioscience, The University of Queensland

10:00 – 10:30

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Nuclei acid-sensing signaling in neurodegeneration
Li Gan, Weill Cornell Medicine

10:30 – 11:00

Coffee break (posters & industry exhibition)

11:00 – 11:15

Blitz talks (selected from abstracts):

Intraparenchymal administration of naïve B lymphocytes protects cognitive function and modulates local neuroinflammation in experimental hemorrhagic stroke
(Saumya Maheshwari, Vaccine & Immunotherapy Center, Harvard Medical School and Massachussetts General Hospital)

Early Neuronal Reprogramming and Cell Cycle re-entry Shape Alzheimer’s Disease Cascade
(Gali Schwartz, The Hebrew University of Jerusalem )

11:15 – 11:45

Bénédicte Py, responsable de l'équipe "Inflammasome NLRP3" à l'unité de recherche Inserm 1111 "Centre international de recherche en infectiologie (CIRI)", Lyon. Le 9 février 2016, Maison de la Chimie, Paris.

New insights on the regulation of the NLRP3 inflammasome
Bénédicte Py, International Center for Infectiology Research, Inserm

Session 6: Neurodegeneration

11:45 – 12:45

MG Spillantini photo_cropped

Plenary Talk 4: The interplay between tau pathology and neuroinflammation
Maria Grazia Spillantini, Cambridge University

12:45 – 13:45

Lunch (posters & industry exhibition)

13:45 – 14:15

Poster session & industry exhibition

14:15 – 14:45

Magdalena Sastre

The inflammatory regulation of APP processing and Aβ pathology
Magdalena Sastre, Imperial College London

14:45 – 15:15

Foto Hugo Peluffo

Role of microglia/macrophage CD300f immune receptor in Alzheimer’s disease
Hugo Peluffo, University of Barcelona

15:15 – 15:30

Blitz talks (selected from abstracts):

SOCS proteins as novel inflammatory targets in Alzheimer’s disease
(Adriana Gea González, Institute of Neurosciences, Alicante)

Recruitment of γδT17 cell contributes to disease progression in a C9orf72 mouse model of amyotrophic lateral sclerosis
(Jianxin Liu, University of Munich)

15:30 – 16:00

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Effects of glial senescence on neurodegeneration
Darren Baker, Mayo Clinic

16:00 – 16:30

Coffee break (posters & industry exhibition)

Session 7: Technical Developments

16:30 – 17:30

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Plenary Talk 5: Divergent Neuro-Immune Interactions Shaping Disease and Aging: Insights from snRNA-seq
Naomi Habib, ELSC Center for Brain Sciences, Hebrew University of Jerusalem

17:30 – 18:00

Oliver_Fiehn

Mapping the Rodent Brain Metabolome
Oliver Fiehn, University of California, Davis

18:00 – 18:10

BarryLynch

Sponsor pitch: NULISA – Ultra-Sensitive Profiling of CNS Disease & Neuroinflammatory blood-based biomarkers
Barry Lynch, Alamar Biosciences

18:10 – 18:40

francisco javier quintana

The epigenetic and metabolic control of astrocytes
Francisco Quintana, Harvard Medical School

18:45 – 21:30

Networking dinner with poster session and industry exhibition

Session 8: Clinical Aspects of Neuroinflammation

9:00 – 10:00

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Plenary talk 6: Imaging microglial and astrocyte reactivity in Alzheimer’s trajectory: How to intervene?
Paul Edison, Imperial College London

10:00 – 10:30

Cambridge Maura Malpetti

Imaging microglia with PET in Alzheimer’s disease and non-AD neurodegenerative diseases
Maura Malpetti, UK Dementia Research Institute, Cambridge University

10:30 – 11:00

Coffee break (posters & industry exhibition)

11:00 – 11:30

Teunissen_Charlotte

Inflammatory biomarkers in CSF and blood
Charlotte Teunissen, Amsterdam UMC

11:30 – 12:00

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Cellular communities drive trajectories leading to Alzheimer’s disease or alternative brain aging
Philip de Jager, Columbia University Medical Center

12:00 – 12:15

Blitz talks (selected from abstracts):

Galectin-3 Deletion Ameliorates Tau Pathology and Attenuates Aberrant Hypermyelination in a Tauopathy Model
(Lluís Camprubí-Ferrer, Lund University)

Fasting followed by time-restricted eating leads to sustained symptom improvement in patients with Parkinson’s disease
(Bérénice Hansen, University of Luxembourg)

12:15 – 13:00

Lunch (posters & industry exhibition)

13:00 – 13:30

Poster session & industry exhibition

Section 9: Neurodegeneration Pathology

13:30 – 14:30

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Plenary Talk 7: Cryo-EM structures of pathological amyloid filaments from the human brain
Michel Goedert, Cambridge University

14:30 – 15:00

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The impact of TDP-43 proteinopathy on neurodegeneration in Alzheimer’s disease and amyotrophic lateral sclerosis
Dietmar Thal, University of Leuven

15:00 – 15:15

Blitz talks (selected from abstracts):

Escaping Silencing: The Role of Xi Escapee Genes in Sex-Specific Microglial Dysfunction in Alzheimer’s Disease
(Sofie Amalie Andersen, University of Copenhagen)

Integrated transcriptomics identifies a rim-localised microglia state in multiple sclerosis lesion expansion
(Mirjam Koster, University of Groningen)

15:15 – 15.45

Coffee break (posters & industry exhibition)

15:45 – 16:15

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Role of microglial inflammation in progression of proteinopathies
Seung-Jae Lee, Seoul National University College of Medicine

Session 10: Neurotransmitters

16:15 – 17:15

Hermona Soreq, lab, students, collaboration

Plenary Talk 8: Cholinergic-targeted transfer RNA fragments in health and brain diseases
Hermona Soreq, Edmond and Lily Safra Center for brain Sciences, Hebrew University

17:15 – 17:45

Photo by Dwight C. Andrews/McGovern Medical School at UTHealth Office of Communications
Dr. Wei Cao - Anesthesiology

The role of type I interferon response in Alzheimer’s disease
Wei Cao, University of Texas Health Science Center Houston

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