08:45 – 09:00
Welcome words
Michael Heneka, Director, Luxembourg Centre for Systems Biomedicine
Session 1: Microglia
Chair: Richard Ransohoff, Partner at Third Rock Ventures
09:00 – 10:00
Plenary Talk 1: Microglia in the diseased human CNS, from an -omics perspective
Bart Eggen, University Medical Center Groningen
10:00 – 10:30
Microglia regulation of activity-dependent changes in neuronal metabolism and translation
Eric Klann, New York University
10:30 – 11:00
Coffee break, industry exhibition and posters (n° 0-35)
11:00 – 11:30
Disrupting Pathogenic Links between Neural Network and Immune Cell Dysfunctions in Alzheimer’s Disease
Lennart Mucke, Gladstone Institute of Neurological Disease, University of California, San Francisco
11:30 – 12:00
Impact of microglia on neuronal circuit functions
Tarja Malm, A.I. Virtanen Institute, University of Eastern Finland
12:00 – 12:15
Exploring the effect of chronic synaptic activity inhibition on microglia dynamics in a mouse model of Alzheimer’s disease
Davide Tampellini, Institut Professeur Baulieu
12:15 – 12:30
Luxembourg National Research Fund presentation
Gideon Gießelmann, Programme Manager, Luxembourg National Research Fund
12:15 – 14:00
Lunch, industry exhibition and posters (n° 0-35)
Session 2: Oligodendrocytes
Chair: Douglas Feinstein, University of Illinois, College of Medicine
14:00 – 15:00
Plenary Talk 2: The role glia cells in de- and remyelination
Mikael Simons, Technical University Munich and German Center for Neurodegenerative Diseases (DZNE)
15:00 – 15:30
Oligodendrocytes in brain energy metabolism and Alzheimer’s disease
Klaus-Armin Nave, Max Planck Institute of Multidisciplinary Sciences, University of Göttingen
15:30 – 15:45
Blitz Talks (selected from abstracts):
The transcription factor Pax6 regulates microglia phenotype and controls neuroinflammation (Klaus Hämäläinen, University of Paris Cité)
The protective PLCγ2-P522R variant enhances microglia immunometabolism
(Heli Jeskanen, University of Eastern Finland)
15:45 – 16:15
Coffee break, industry exhibition and posters (n° 0-35)
Session 3: Astrocytes
Chair: David Bouvier, Luxembourg centre for Systems Biomedicine
16:45 – 17:00
Blitz Talks (selected from abstracts):
Midbrain Monoaminergic Deficits drive Hippocampal Microglia-Astrocyte reactivity and Accelerate Alzheimer’s Pathology
(Gilda Loffredo, Università Campus Bio-Medico di Roma)
ABCA7 loss-of-function microglia lose their phagocytic ability and reactive profile in a humanized model of AD
(Jessie Premereur,VIB-CMN)
Session 4: Epigenetics
Chair: Hermona Soreq, the Hebrew University
17:00 – 17:30
Non-Coding RNAs and Epigenetic Regulation in Astrocytes and Microglia: Insights into Neurodegenerative Diseases
André Fischer, University Medical Center Göttingen and German Center for Neurodegenerative Diseases (DZNE)
17:30 – 18:00
Single-Cell and Spatial Transcriptomics and Epigenomics of Oligodendroglia in Development and in Multiple Sclerosis
Gonçalo Castelo-Branco, Karolinska Institute
18:00 – 18:30
How the concept of glia evolved – a historical journey
Helmut Kettenmann, Shenzhen University of Advanced Technology
Session 5: Inflammasomes & cGAS/STING
Chair: Michael Heneka, Luxembourg Centre for Systems Biomedicine
9:00 – 10:00
Plenary Talk 3: Inflammasomes: from fundamental biology to new therapeutics for neuroinflammation
Kate Schroeder, Institute for Molecular Bioscience, The University of Queensland
10:30 – 11:00
Coffee break, industry exhibition and posters (n° 36-70)
11:00 – 11:15
Blitz talks (selected from abstracts):
Intraparenchymal administration of naïve B lymphocytes protects cognitive function and modulates local neuroinflammation in experimental hemorrhagic stroke
(Saumya Maheshwari, Vaccine & Immunotherapy Center, Harvard Medical School and Massachussetts General Hospital)
Early Neuronal Reprogramming and Cell Cycle re-entry Shape Alzheimer’s Disease Cascade
(Gali Schwartz, The Hebrew University of Jerusalem )
11:15 – 11:45
New insights on the regulation of the NLRP3 inflammasome
Bénédicte Py, International Center for Infectiology Research, Inserm
Session 6: Neurodegeneration
Chair: Marcia Gordon, Michigan State University
11:45 – 12:45
Plenary Talk 4: The interplay between tau pathology and neuroinflammation
Maria Grazia Spillantini, Cambridge University
12:45 – 14:15
Lunch, industry exhibition and posters (n° 36-70)
14:15 – 14:45
The inflammatory regulation of APP processing and Aβ pathology
Magdalena Sastre, Imperial College London
14:45 – 15:15
Role of microglia/macrophage CD300f immune receptor in Alzheimer’s disease
Hugo Peluffo, University of Barcelona
15:15 – 15:30
Blitz talks (selected from abstracts):
SOCS proteins as novel inflammatory targets in Alzheimer’s disease
(Adriana Gea González, Institute of Neurosciences, Alicante)
Recruitment of γδT17 cell contributes to disease progression in a C9orf72 mouse model of amyotrophic lateral sclerosis
(Jianxin Liu, University of Munich)
16:00 – 16:30
Coffee break, industry exhibition and posters (n° 36-70)
Session 7: Technical Developments
Chair: Michael Heneka, Luxembourg Centre for Systems Biomedicine
16:30 – 17:30
Plenary Talk 5: Divergent Neuro-Immune Interactions Shaping Disease and Aging: Insights from snRNA-seq
Naomi Habib, ELSC Center for Brain Sciences, Hebrew University of Jerusalem
18:00 – 18:10
Sponsor pitch: NULISA – Ultra-Sensitive Profiling of CNS Disease & Neuroinflammatory blood-based biomarkers
Barry Lynch, Alamar Biosciences
18:10 – 18:40
The epigenetic and metabolic control of astrocytes
Francisco Quintana, Harvard Medical School
18:45 – 21:30
Networking dinner with poster session and industry exhibition
Session 8: Clinical Aspects of Neuroinflammation
Chair: Peter-Andreas Löschmann, Berlin Capital Office of “gesundheitspolitik.de”
9:00 – 10:00
Plenary talk 6: Imaging microglial and astrocyte reactivity in Alzheimer’s trajectory: How to intervene?
Paul Edison, Imperial College London
10:00 – 10:30
Imaging microglia with PET in Alzheimer’s disease and non-AD neurodegenerative diseases
Maura Malpetti, UK Dementia Research Institute, Cambridge University
10:30 – 11:00
Coffee break, industry exhibition, and posters (n° 71-104)
11:30 – 12:00
Cellular communities drive trajectories leading to Alzheimer’s disease or alternative brain aging
Philip de Jager, Columbia University Medical Center
12:00 – 12:15
Blitz talks (selected from abstracts):
Galectin-3 Deletion Ameliorates Tau Pathology and Attenuates Aberrant Hypermyelination in a Tauopathy Model
(Lluís Camprubí-Ferrer, Lund University)
Fasting followed by time-restricted eating leads to sustained symptom improvement in patients with Parkinson’s disease
(Bérénice Hansen, University of Luxembourg)
12:15 – 13:30
Lunch, industry exhibition, and posters (n° 71-104)
Section 9: Neurodegeneration Pathology
Chair: Kerry O’Bannion, University of Rochester School of Medicine
13:30 – 14:30
Plenary Talk 7: Cryo-EM structures of pathological amyloid filaments from the human brain
Michel Goedert, Cambridge University
14:30 – 15:00
The impact of TDP-43 proteinopathy on neurodegeneration in Alzheimer’s disease and amyotrophic lateral sclerosis
Dietmar Thal, University of Leuven
15:00 – 15:15
Blitz talks (selected from abstracts):
Escaping Silencing: The Role of Xi Escapee Genes in Sex-Specific Microglial Dysfunction in Alzheimer’s Disease
(Sofie Amalie Andersen, University of Copenhagen)
Integrated transcriptomics identifies a rim-localised microglia state in multiple sclerosis lesion expansion
(Mirjam Koster, University of Groningen)
15:15 – 15.45
Coffee break, industry exhibition, and posters (n° 71-104)
15:45 – 16:15
Role of microglial inflammation in progression of proteinopathies
Seung-Jae Lee, Seoul National University College of Medicine
Session 10: Neurotransmitters
Chair: David Morgan, Clearwater
16:15 – 17:15
Plenary Talk 8: Cholinergic-targeted transfer RNA fragments in health and brain diseases
Hermona Soreq, Edmond and Lily Safra Center for brain Sciences, Hebrew University
17:15 – 17:45
The role of type I interferon response in Alzheimer’s disease
Wei Cao, University of Texas Health Science Center Houston
17:45 – 18:00
Poster prize ceremony and wrap up